Left caudate volume

1. Fazekas score mediates left caudate volume in humans (indirect effect = 1.761, P=0.035, 23.0% of total effect).

   “Fazekas scores were found to partially mediate the relationship between the p-Tau 181 levels and left caudate volumes (indirect effect =1.761, P=0.035)”

   Humanscognitively normalbrain

   Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging

   Quantitative imaging in medicine and surgery·23 Jan 2026

More on Fazekas score

1. White matter hyperintensity is associated with left caudate volume in humans (P=0.042).

   “left caudate nucleus (P=0.042) was enlarged in the participants with severe WMH”

   Humanssevere white matter hyperintensity vs mildbrain

   Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging

   Quantitative imaging in medicine and surgery·23 Jan 2026