eLife
PCBP2 as an intrinsic aging factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis
Preprint: experiments in human cellsFGF signaling
Papers on Factor 2
714 papers28 new in 30 days
Thursday, February 8
Friday, February 2
International Journal of Biological Macromolecules
Nicotinamide mononucleotide based hyaluronic acid methacryloyl hybrid hydrogel regulating stem cells fate for bone regeneration via SIRT1/RUNX2 signaling
Experiments in miceNicotinamide mononucleotide
Tuesday, January 23
Monday, January 22
Endocrine Connections
Exercise alleviates renal interstitial fibrosis by ameliorating the Sirt1-mediated TGF-β1/Smad3 pathway in T2DM mice
Experiments in miceExercise
Sunday, January 7
Rejuvenation Research
Melatonin Ameliorates Sevoflurane Anesthesia-Induced Deficits in Learning and Memory of Aged Mice Through Nrf2 Signaling Related Ferroptosis
Experiments in miceMelatonin
Tuesday, January 2
Frontiers in Cell and Developmental Biology
The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans
Experiments in wormsIntegrated stress response
Monday, January 1
Journal of Clinical Biochemistry and Nutrition
Trans-resveratrol reduced hepatic oxidative stress in an animal model without inducing an upregulation of nuclear factor erythroid 2-related factor 2
Experiments in miceOxidative stress and ROS signaling
Current Pharmaceutical Biotechnology
Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review
Systematic reviewFisetin
Friday, December 29
Toxicology and Applied Pharmacology
NMNATs expression inhibition mediated NAD⁺ deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice
Experiments in miceNAD+
Thursday, December 28
Wednesday, December 27
Thursday, December 21
Imaging Neuroscience
Unique information from common diffusion MRI models about white-matter differences across the human adult lifespan
Cross-sectional study of 651 peopleMechanisms
Monday, December 11
Turkish Journal of Medical Sciences
Predictive value of preoperative Fried Frailty Phenotype assessment and serum biomarkers on the prognosis of elderly patients with femoral neck fracture under general anesthesia within 3 months after surgery
Cohort study of 150 peopleFried frailty phenotype
Monday, December 4
Journal of Microbiology and Biotechnology
In Vitro and In Vivo Bone-Forming Effect of a Low-Molecular-Weight Collagen Peptide
Experiments in animalsInterventions
Saturday, December 2
Wednesday, November 29
The British Journal of Nutrition
Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing?
ReviewMechanisms
Saturday, November 25
Monday, November 13
Scientific Reports
The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury
Experiments in ratsAerobic exercise
Inflammopharmacology
A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications
Systematic reviewType 2 diabetes
Thursday, November 2
Molecular and Cellular Biochemistry
NRF2 signaling pathway and telomere length in aging and age-related diseases
Clinical Kidney Journal
Early aging and premature vascular aging in chronic kidney disease
ReviewKidney
Chemical Biology & Drug Design
Kaempferol exerts antioxidant effects in age-related diminished ovarian reserve by regulating the HSP90/NRF2 pathway
Experiments in miceDiminished ovarian reserve
Tuesday, October 31
Journal of Orthopaedic Surgery and Research
MiR-210 promotes bone formation in ovariectomized rats by regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells through downregulation of EPHA2
Experiments in animalsMechanisms
Monday, October 30
Stem Cells International
Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation
Experiments in human cellsNRF2–KEAP1 antioxidant response
Friday, October 27
Current Research in Food Science
Kahweol, a coffee diterpene, increases lifespan via insulin/insulin-like growth factor-1 and AMP-activated protein kinase signaling pathways in Caenorhabditiselegans
Experiments in wormsInterventions
Tuesday, October 24
The Journal of Prevention of Alzheimer's Disease
Protocol for the Brain Health Support Program Study of the Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP): A Prospective 12-Month Intervention Study
Study protocolDementia
Friday, October 20
Sunday, October 15
Biochemical and Biophysical Research Communications
Inokosterone activates the BMP2 to promote the osteogenic differentiation of bone marrow mesenchymal stem cells and improve bone loss in ovariectomized rats
Experiments in animalsInterventions