Journal of Cachexia, Sarcopenia and Muscle·Aug 3Aging-related hyperphosphatemia impairs myogenic differentiation and enhances fibrosis in skeletal muscleExperiments in miceStem cell differentiationPaper
Frontiers in Aging Neuroscience·Jul 30The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled TrialStudy protocolDementiaPaper
Aging·Jul 22Atorvastatin attenuates intermittent hypoxia-induced myocardial oxidative stress in a mouse obstructive sleep apnea modelExperiments in 48 miceAtorvastatinPaper
Annals of Translational Medicine·Jul 20Caloric restriction inhibits renal artery ageing by reducing endothelin-1 expressionExperiments in ratsDietary restrictionPaper
bioRxiv·Jul 19Machine-learning-based predictions of caloric restriction associations across ageing-related genesPreprint: computational studyMechanismsPaper
Scientific Reports·Jul 18Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosisExperiments in miceEpigenetic regulation of gene expressionPaper
Biochemical Pharmacology·Jul 10Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosisExperiments in zebrafishFisetinPaper
International Journal of Molecular Sciences·Jul 3Uremic Toxins and Frailty in Patients with Chronic Kidney Disease: A Molecular InsightReviewKidneyPaper
Experimental Cell Research·Jun 10Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathwayExperiments in miceNRF2–KEAP1 antioxidant responsePaper
Cell Death & Disease·Jun 10G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescenceExperiments in miceCellular senescencePaper
Biomedicine & Pharmacotherapy·May 28Mechanistic insights and perspectives involved in neuroprotective action of quercetinReviewQuercetinPaper
Scientific Reports·May 28Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout miceExperiments in miceMusclePaper
Science Advances·May 28Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator miceExperiments in miceType I interferon signalingPaper
Journal of Ginseng Research·May 25Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signalingExperiments in ratsRenal fibrosisPaper
Communications Biology·May 23Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injuryExperiments in miceTelomerase and telomere maintenancePaper
Oxidative Medicine and Cellular Longevity·May 21The Keap1-Nrf2 System: A Mediator between Oxidative Stress and AgingReviewNRF2–KEAP1 antioxidant responsePaper
Antioxidants & Redox Signaling·May 20Inflammation and Oxidative Stress in Chronic Kidney Disease and Dialysis PatientsReviewOxidative stress and ROS signalingPaper
Food Research International·May 17Drosophila as an emerging model organism for studies of food-derived antioxidantsReviewInterventionsPaper
Human & Experimental Toxicology·May 5Nicotinamide improves NAD⁺ levels to protect against acetaminophen-induced acute liver injury in miceExperiments in miceNicotinamidePaper
Neuroscience·May 3Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse BrainExperiments in miceIntermittent fastingPaper
Frontiers in Aging Neuroscience·Apr 28The Potential Role of Protein Kinase R as a Regulator of Age-Related NeurodegenerationReviewMechanismsPaper
Aging·Apr 27Translational control of gene expression by eIF2 modulates proteostasis and extends lifespanExperiments in yeastMechanismsPaper
Molecular and Cellular Biology·Apr 21YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging TunicatesExperiments in model organismsMitochondrionPaper
Research Square·Apr 13Natural Astaxanthin From Haematococcus Pluvialis Enhanced Antioxidant Capacity And Improved Semen Quality In Aging Layer Breeder Roosters Through The Mitogen-Activated Protein Kinase/Nuclear Factor-Erythroid 2-Related Factor 2 (MAPK/Nrf2) PathwayPreprint: experiments in 96 chickensInterventionsPaper
Experimental Gerontology·Mar 14MyomiR-OsteomiR crosstalk induced by different modes and intensities of exercise training and its role in controlling osteogenic differentiation in old male Wistar ratsExperiments in 50 ratsHigh-intensity resistance trainingPaper
Diabetology & Metabolic Syndrome·Feb 18Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesityNon-randomized trial in 13 peopleBariatric surgeryPaper
Frontiers in Genetics·Jan 29Pilot Study on Genetic Associations With Age-Related SarcopeniaStudy in peopleBiomarkersPaper
Neurobiology of Aging·Jan 25Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during agingExperiments in miceInterventionsPaper
GeroScience·Jan 9Access to females and early life castration individually extend maximal but not median lifespan in male miceExperiments in miceInterventionsPaper