Endotrophin
- Humans2
Effects
1Total cholesterol
mediatesin humans1
1 study
Total cholesterol
mediatesin humans1
Endotrophin mediates total cholesterol in humans (15% [4, 51]).
“Exploratory mediation analyses showed that endotrophin mediated 15% [4, 51] of the effect of fat mass on total cholesterol.”
Human trialmediating effect of fat mass on total cholesterol
Dynamic regulation of circulating endotrophin by changes in fat mass in humans
Metabolism: clinical and experimental19 Jun 2026
Upstream
1Acutely hospitalized older patients
upin humans1
1 study
Acutely hospitalized older patients
upin humans1
Acutely hospitalized older patients increase endotrophin in humans.
“At T0, endotrophin levels were significantly elevated in Older patients compared to Older controls, while Young controls displayed substantially lower levels.”
Humansacutely hospitalized older patients vs older controls
Circulating endotrophin reflects inflammaging and mortality risk in older adults
GeroScience23 Feb 2026
Associations
4Fat mass
upin humans1
1 study
Fat mass
upin humans1
Fat mass is associated with endotrophin in humans (B = 0.76 ng/mL/kg).
“Changes in fat mass were positively associated with changes in circulating endotrophin (unstandardized B-coefficient [95% CI] = 0.76 [0.45, 1.07] ng/mL/kg and 0.89 [0.51, 1.28] ng/mL/percentage point, P < 0.001).”
Human trial
Dynamic regulation of circulating endotrophin by changes in fat mass in humans
Metabolism: clinical and experimental19 Jun 2026
Mortality
upin humans1
1 study
Mortality
upin humans1
Endotrophin predicts mortality in humans.
“elevated endotrophin levels at T−1 and T0 were associated with all-cause mortality, independent of demographic and clinical factors”
Humansin acutely hospitalized older patients
Circulating endotrophin reflects inflammaging and mortality risk in older adults
GeroScience23 Feb 2026
Physical function
downin humans1
1 study
Physical function
downin humans1
Endotrophin is associated with physical function in humans.
“Higher endotrophin at T0 correlated with markers of inflammation, frailty, and reduced physical function.”
Humansat T0
Circulating endotrophin reflects inflammaging and mortality risk in older adults
GeroScience23 Feb 2026
Frailty
upin humans1
1 study
Frailty
upin humans1
Endotrophin is associated with frailty in humans.
“Higher endotrophin at T0 correlated with markers of inflammation, frailty, and reduced physical function.”
Humansat T0
Circulating endotrophin reflects inflammaging and mortality risk in older adults
GeroScience23 Feb 2026
Funding
1 grant since 2023Vlaamse regering