2 papers3 findings
Tirzepatide
downin humans1
Tirzepatide decreases eGFR decline in humans (ETD 3.9 ml/min per 1.73m2, p<0.001).
“A significantly smaller decline in eGFR was observed with pooled TZP (-1.6±0.5 ml/min per 1.73m2) compared to placebo (-5.5±1.0 ml/min per 1.73m2) after 176 weeks”
Human trialin participants with obesity or overweight and prediabetes176 weeks
ADA Scientific Sessions 2025 abstract13 Jun 2025
Dietary animal protein
no changein humans1
Dietary animal protein has no effect on eGFR decline in humans (P = 0.84).
“The intake of animal protein was not associated with eGFR decline (P = 0.84).”
Humans10 yearsfemalesn = 1,374
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association27 Aug 2021
Dietary plant protein
downin humans1
Dietary plant protein decreases eGFR decline in humans (reduced by 0.12 mL/min/1.73 m2 per 10 g (95% CI 0.01-0.23)).
“For each 10 g of plant protein, the yearly decline in eGFR was reduced by 0.12 mL/min/1.73 m2 (95% CI 0.01-0.23)”
Humans10 yearsfemalesn = 1,374
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association27 Aug 2021
National Institute of Diabetes and Digestive and Kidney DiseasesUS$133.9k
The two-year combined outcome rate was 15.6% for sodium-glucose cotransporter 2 inhibitors versus 19.9% for renin-angiotensin system inhibitors, the comparison drug…The two-year combined outcome rate was 15.6% for sodium-glucose cotransporter 2 inhibitors versus 19.9% for renin-angiotensin system inhibitors, the comparison drug class.
In geriatric wards, a heart, lung and kidney disease pattern was associated with 2.24 times the odds of decline versus two other disease patterns.In geriatric wards, a heart, lung and kidney disease pattern was associated with 2.24 times the odds of decline versus two other disease patterns.
Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.
Higher fractional uric acid excretion was associated with eGFR decline after adjustment for confounders (odds ratio 1.218, 95% CI 1.176–1.262).Higher fractional uric acid excretion was associated with eGFR decline after adjustment for confounders (odds ratio 1.218, 95% CI 1.176–1.262).