EEAA

1. COVID-19 increases EEAA in humans.

   “both the intrinsic epigenetic age acceleration (IEAA) and the extrinsic epigenetic age acceleration (EEAA) are accelerated”

   Humansmild COVID-19

   GrimAge is elevated in older adults with mild COVID-19 an exploratory analysis

   GeroScience·15 Feb 2024

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1. Body mass index increases EEAA in humans.

   “longitudinal data suggests that an increase in BMI is associated with increase in both EEAA and IEAA.”

   Humansblood

   Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

   Aging·14 Feb 2017

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1. EEAA is associated with AD Pattern Similarity score in humans (b=0.0115, 95% CI 0.002 – 0.021).

   “and EEAA (b=0.0115, 95% CI 0.002 – 0.021; p = .02) were associated with the AD‐PS score, with greater age acceleration associated with higher AD‐PS score.”

   Humansadjusted for covariates8 yearsfemalesn = 1,196

   Prospective associations of epigenetic age estimators with Alzheimer's disease atrophy patterns among older women: The Women's Health Initiative Memory Study

   AAIC 2025 abstract·24 Dec 2025

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1. Education is associated with EEAA in humans (p=3x10−5).

   “education (p=3x10−5)”

   Humansblood

   Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

   Aging·14 Feb 2017

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1. Moderate alcohol consumption is associated with EEAA in humans (p=0.01).

   “moderate alcohol consumption (p=0.01)”

   Humansblood

   Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

   Aging·14 Feb 2017

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1. Fish intake is associated with EEAA in humans (p=0.02).

   “Extrinsic epigenetic age acceleration (EEAA) exhibits significant associations with fish intake (p=0.02)”

   Humansblood

   Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

   Aging·14 Feb 2017

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