AD Pattern Similarity score

1. EEAA is associated with AD Pattern Similarity score in humans (b=0.0115, 95% CI 0.002 – 0.021).

   “and EEAA (b=0.0115, 95% CI 0.002 – 0.021; p = .02) were associated with the AD‐PS score, with greater age acceleration associated with higher AD‐PS score.”

   Humansadjusted for covariates8 yearsfemalesn = 1,196

   Prospective associations of epigenetic age estimators with Alzheimer's disease atrophy patterns among older women: The Women's Health Initiative Memory Study

   AAIC 2025 abstract·24 Dec 2025

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1. GrimAge2 is associated with AD Pattern Similarity score in humans (b=0.0172, 95% CI 0.006 – 0.029).

   “Of the seven epigenetic age estimators, only AgeAccelGrim2 (b=0.0172, 95% CI 0.006 – 0.029; p = .003) and EEAA (b=0.0115, 95% CI 0.002 – 0.021; p = .02) were associated with the AD‐PS score”

   Humansadjusted for covariates8 yearsfemalesn = 1,196

   Prospective associations of epigenetic age estimators with Alzheimer's disease atrophy patterns among older women: The Women's Health Initiative Memory Study

   AAIC 2025 abstract·24 Dec 2025

More on GrimAge2