DNAm-PAD PhenoAge plus Brain-PAD

1. DNAm-PAD PhenoAge plus Brain-PAD predicts lifetime major depressive disorder in humans (AUC=0.69; R2=9%).

   “DNAm-PAD and Brain-PAD demonstrated shared and distinctive contributions to lifetime MDD (DNAm-PAD PhenoAge plus Brain-PAD explained maximum variance, AUC=0.69, R 2 =9%).”

   HumansCombined DNAm-PAD PhenoAge and Brain-PAD model

   Epigenetic and Structural Brain Aging and their Associations with Major Depressive Disorder and Inflammatory Markers

   medRxiv·22 Nov 2024Preprint

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