BrainAge and DNA methylation age

1. Major depressive disorder is associated with BrainAge and DNA methylation age in humans (1.60–2.45 years higher than controls).

   “Lifetime MDD cases showed significantly higher BrainAge and DNAmAge, ranging from 1.60-2.45 years increase compared to controls”

   HumansGeneration Scotland; lifetime MDD cases compared with controls; excludes Horvath DNAmAge

   Epigenetic and Structural Brain Aging and their Associations with Major Depressive Disorder and Inflammatory Markers

   medRxiv·22 Nov 2024Preprint

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