brain-PAD

1. brain-PAD has no effect on dementia in humans (HR 1.01, 95% CI 0.99-1.04).

   Humansin MCI patientsn = 387

   Comparison of Brain Age With Standard MRI Assessment for Dementia Risk Stratification in Subjective and Mild Cognitive Impairment

   Neurology·10 Aug 2026

More on Dementia

1. brain-PAD predicts dementia in humans (HR 1.09, 95% CI 1.03-1.15).

   Humansin SCD patientsn = 412

   Comparison of Brain Age With Standard MRI Assessment for Dementia Risk Stratification in Subjective and Mild Cognitive Impairment

   Neurology·10 Aug 2026

2. brain-PAD raises the risk of dementia in humans (HR 1.04, 95% CI 1.02-1.06).

   Humansin SCD and MCI patientsn = 799

   Comparison of Brain Age With Standard MRI Assessment for Dementia Risk Stratification in Subjective and Mild Cognitive Impairment

   Neurology·10 Aug 2026

More on Dementia

1. Discordant subjective-objective cognitive profiles are associated with brain-PAD in humans.

   Humansdiscordant profiles

   Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 Aug 2026