Demyelination

Protein loss promotes age-linked brain cell activation in mice

In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.

Limit: Whether activation is adaptive or an early, compensated stage of chronic activation remains unknown

Senescent CD4 T cells drive age-associated autoimmunity in mice and humans

Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.