Cytoplasmic DNA

2 papers

Animals2

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3 in 12 months

Nature Aging26 Aug

cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation

Experiments in miceTransposable element activity

Archives of Pharmacal Research24 Aug

cGAS-STING signaling in aging and age-related diseases: therapeutic promise and precaution

ReviewcGAS–STING signalling

bioRxiv20 Aug

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

Preprint: experiments in human cellsCellular senescence

PNAS14 Sep

NAD⁺ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING

Experiments in miceAlzheimer's disease

Nature Communications28 Mar

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Experiments in miceSenescence-associated secretory phenotype (SASP)