Cytoplasmic chromatin

1 paper

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Nature CommunicationsSep 17

CK2α restriction of STING accumulation underlies systemic aging

Experiments in miceSTING1

Nature AgingAug 21

Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline

Experiments in miceCellular senescence

iScienceJul 28

TRF2 enriched cytoplasmic chromatin drives cGAS-STAT1-mediated inflammation in senescence

Experiments in cellsCellular senescence

Redox BiologyJun 21

XRCC1 deficiency drives telomeric chromatin leakage, inflammatory signalling and senescence

Experiments in human cellscGAS–STING signalling

Nature AgingJun 17

Nuclear export of R-loop by the DDX1 and XPO1 complex promotes senescence-associated secretory phenotype and inflammaging

Experiments in animalsSenescence-associated secretory phenotype (SASP)

Nature CommunicationsJun 7

Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice

Experiments in miceInterventions

Research SquareFeb 6

Senescent cells secrete chromatin components via senescence-associated extracellular particles

Preprint: experiments in miceCellular senescence

Nature AgingJan 17

Metformin inhibits nuclear egress of chromatin fragments in senescence and aging

Experiments in miceMetformin

bioRxivDec 31

Senescent cells secrete chromatin components via senescence-associated extracellular particles

Preprint: experiments in miceCellular senescence

The EMBO JournalAug 30

Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling?

CommentarycGAS–STING signalling