Cristae density

2 papers2 findings

Animals2

Upstream

1

Cardiovascular aging

downin humans1downin mice1

1 study

Cardiovascular aging decreases cristae density in mice.
“in aged mice's hearts, cristae undergo ultrastructural remodeling processes, resulting in a decrease in cristae density and width.”
Animalsheart
Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts
Proceedings of the National Academy of Sciences of the United States of America30 Dec 2025
Cardiovascular aging decreases cristae density in humans.
“aged patients' hearts displayed reduced cristae density as seen by transmission electron microscopy (TEM)”
Humansheart
Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts
Proceedings of the National Academy of Sciences of the United States of America30 Dec 2025

Latest

1 in 12 months

PNAS30 Dec

Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts

Experiments in miceOxidative phosphorylation

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids10 Sep

Age-related changes in cardiolipin profile and functional consequences of altered fatty acid supply

Experiments in miceOxidative phosphorylation