Collagen density

6 papers2 findings

Humans1
Animals4
In silico1

Interventions

2

Dasatinib + quercetin

upin mice1

1 study

Dasatinib + quercetin increases collagen density in mice.
“Additionally, D + Q-treated aged human skin grafts exhibited increased collagen density and suppression of the SASP compared with control grafts.”
Animalsaged human whole-skin grafts transplanted subcutaneously onto nude mice; compared with vehicleaged human skin grafts30 days
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology15 Apr 2024

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Navitoclax

upin humans1

1 study

Navitoclax increases collagen density in humans.
“and an increase in collagen density.”
Animalshuman skin graft mouse modelskin
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model
Rejuvenation research16 Jan 2023

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Latest

6 in 12 months

Journal of Functional Biomaterials24 Sep

Concentration-Dependent Rheological Properties of Atelocollagen Are Associated with Fibroblast Mechanotransduction and Collagen Remodeling in Aged Skin

Experiments in miceSkin

Stem Cells Translational Medicine1 Sep

MSCs derived from ADSC-reprogrammed iPSCs exhibit enhanced therapeutic potential for treating skin fibrosis

Experiments in miceSkin

Aesthetic Plastic Surgery18 Jun

A Computational Trial of Dermal Mechanotransduction in GLP-1 Receptor Agonist-Associated Premature Facial Ageing

Computational studyGLP-1 receptor agonists

Biomedicine & Pharmacotherapy11 Jun

Ovarian function is required for functional recovery of muscle by human ESC-derived mesenchymal progenitor cells in postmenopausal sarcopenic mice

Experiments in miceSarcopenia

Canadian Journal of Veterinary Research20 Apr

Histological properties of the distal sesamoidean impar ligament in racing Thoroughbreds and Quarter horses

Experiments in animalsMechanisms

International Journal of Molecular Sciences30 Dec

Atelocollagen Increases Collagen Synthesis by Promoting Glycine Transporter 1 in Aged Mouse Skin

Experiments in miceSkin

International Journal of Molecular Sciences13 Sep

Polynucleotides Enhance Collagen Synthesis via Modulating Phosphoenolpyruvate Carboxykinase 1 in Senescent Macrophages: Experimental Evidence

Experiments in animalsInterventions

Scientific Reports27 May

Comparison of the effects of fractional microneedle radiofrequency and microneedling on modulating the senescent fibroblast milieu in aged skin

Trial in peopleInterventions

Acta Biomaterialia14 Oct

Effects of age, elastin density, and glycosaminoglycan accumulation on the delamination strength of human thoracic and abdominal aortas

Cross-sectional study of 35 peopleMechanisms

Biogerontology15 Apr

Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo

Experiments in miceDasatinib + quercetin