Circulating insulin

1. Caloric restriction increases circulating insulin in mice (Ins1(+/-):Ins2(-/-) mice; compared with ad libitum feeding).

   “53-week-old Ins1(+/-):Ins2(-/-) mice exhibited a paradoxical increase in circulating insulin in the CR group compared with the ad libitum-fed Ins1(+/-):Ins2(-/-) mice.”

   AnimalsIns1(+/-):Ins2(-/-) mice; compared with ad libitum feeding60% CR dietfemales

   Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin

   Endocrinology·May 4, 2016

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1. Circulating insulin decreases fasting glucose in mice.

   “decreased insulin led to lower fasting glucose and improved insulin sensitivity in aged mice”

   Animals

   Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

   Cell reports·Jul 11, 2017

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1. WDR23 increases circulating insulin in mice (shown by knockout).

   “Wdr23KO mice have increased IDE expression, reduced circulating insulin, and defective insulin responses.”

   Animalsshown by knockout

   Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme

   bioRxiv (Cold Spring Harbor Laboratory)·Nov 25, 2022Preprint

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1. INS2 decreases circulating insulin in mice (-25% to -34%).

   “Halving Ins2 lowered circulating insulin by 25%-34% in aged female mice”

   Animalsfemales

   Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

   Cell reports·Jul 11, 2017

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