WDR23
There are 4 papers on WDR23 in aging research: 1 observational study in people, 3 in animals.
“analysis of human genetic variation in WDR23 across a large naturally aging human cohort in the US Health and Retirement Study reveals a significant association of WDR23 with altered hemoglobin A1C (HbA1c) levels”
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: National Institute on Aging and others
- Humans1
- Animals2
- Model organisms1
Effects
5IDE
downin human cells1downin mice1
2 studies
IDE
downin human cells1downin mice1
WDR23 inhibits IDE in WDR23-deficient human cells.
“Genetically engineered human cell models lacking WDR23 also increase IDE expression”
Cellsin WDR23-deficient human cells
GeroScience
WDR23 decreases IDE in mice (shown by knockout).
“Wdr23KO mice have increased IDE expression”
Animalsshown by knockout
Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Cognitive function
downin mice1
1 study
Cognitive function
downin mice1
WDR23 impairs cognitive function in 3xTg-AD mice.
“Wdr23 knockout mice exhibited improved cognitive function”
Animalsin 3xTg-AD mice
Loss of WDR23 slows the rate of age-related cognitive decline with elevated amyloid burden
Journal of Alzheimer's disease : JAD
Tau pathology
no changein mice1
1 study
Tau pathology
no changein mice1
WDR23 showed no clear effect on tau pathology in 3xTg-AD mice.
“it did not impact tau pathology”
Animalsin 3xTg-AD micebrain
Loss of WDR23 slows the rate of age-related cognitive decline with elevated amyloid burden
Journal of Alzheimer's disease : JAD
Circulating insulin
upin mice1
1 study
Circulating insulin
upin mice1
WDR23 increases circulating insulin in mice (shown by knockout).
“Wdr23KO mice have increased IDE expression, reduced circulating insulin, and defective insulin responses.”
Animalsshown by knockout
Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme
bioRxiv (Cold Spring Harbor Laboratory)Preprint
NFE2L2
is required forin cells1
1 study
NFE2L2
is required forin cells1
WDR23 is required for NFE2L2 in cells (shown by knockdown).
“knockdown of WD40 repeat protein 23 (WDR23), but not Keap1, abolished the effects of CGA on the activation of Nrf2”
Cellsshown by knockdown
The journals of gerontology. Series A, Biological sciences and medical sciences
Associations
1HbA1c
mixedin humans2
2 studies
HbA1c
mixedin humans2
WDR23 is associated with HbA1c in older adults.
“analysis of human genetic variation in WDR23 across a large naturally aging human cohort in the US Health and Retirement Study reveals a significant association of WDR23 with altered hemoglobin A1C (HbA1c) levels”
Humansin older adults
GeroScience
WDR23 is associated with HbA1c in humans.
“reveals a significant association of WDR23 with altered hemoglobin A1C (HbA1c) levels in older adults”
Humans
Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Funding
1 grant since 2019National Institute on AgingUS$2.9m