Molecular Metabolism·Oct 24Diet-induced diabetes driven by proinsulin misfolding reversed by β-cell restExperiments in miceDiabetes mellitusPaper
Research Square·Aug 30Nicotinamide Mononucleotide Restores Pancreatic β-Cell Function in Type 2 Diabetes through SIRT6-HIF-1α-Mediated Mitochondrial Stress Adaptation and Glycolytic ReprogrammingPreprint: experiments in rat cellsNicotinamide mononucleotidePaper
Molecular Biology Reports·Jul 19Molecular basis of insulin resistance and its impact on the brain: the role of physical exerciseReviewInterventionsPaper
Metabolism·Jun 10The effects of acute ketone monoester supplementation on brain insulin responsiveness and cognitive performance: Results of a randomized, double-blind, placebo-controlled crossover trial in older men with overweightRandomized trial in 18 peopleOverweightPaper
ADA Scientific Sessions 2026 Abstract·Jun 6Mechanisms and Consequences of IL-1β-Mediated Changes in β-Cell FunctionExperiments in miceMechanismsPaper
ADA Scientific Sessions 2026 Abstract·Jun 6Forty Weeks of Metformin Alters Regional Insulin Sensitivity but Not Mitochondrial Function in Insulin-Resistant AdultsRandomized trial in 40 peopleMetforminPaper
BMC Medicine·Apr 11Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetesReviewMechanismsPaper
Journal of Neuroendocrinology·Mar 26Effect of metformin on pancreatic neuroendocrine tumors of multiple endocrine neoplasia type 1Cohort study in peopleMetforminPaper
American Journal of Physiology Endocrinology and Metabolism·Jan 7Twelve weeks of voluntary wheel running restores glucagon sensitivity in middle-aged miceExperiments in miceInterventionsPaper
Aging Cell·Dec 23Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in MiceExperiments in miceDietary restrictionPaper
bioRxiv·Jul 11The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetesPreprint: experiments in miceCellular senescencePaper
Preprints.org·Jan 24A Descriptive Review on the Association of Insulin Resistance/Hyperinsulinemia with Increased Mortality RiskPreprint: reviewPopulationsPaper
Biomedicines·Oct 26Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent KillerReviewMechanismsPaper
GeroScience·May 20Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacityGenetic association study in peopleProteostasisPaper
GeroScience·Jan 16Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes in sex-dependent and sex-independent mannersExperiments in miceMetforminPaper
International Journal of Molecular Sciences·Oct 14Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone ProductionExperiments in miceMechanismsPaper
bioRxiv·Nov 25Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzymePreprint: experiments in miceProteostasisPaper
Cells·Nov 12Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-DiabeticsNon-randomized trial in 21 peopleEmpagliflozinPaper
Journal of Endocrinological Investigation·Nov 2Short-term physical exercise controls age-related hyperinsulinemia and improves hepatic metabolism in aged rodentsExperiments in ratsAerobic exercisePaper
Indian Journal of Pediatrics·Jun 16The Relationship of Birth Size and Postnatal Growth with Cellular Senescence in Adults: Data from the New Delhi Birth CohortCohort study of 210 peopleCellular senescencePaper
The EMBO Journal·Jan 14Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetesExperiments in miceMechanismsPaper
Aging Cell·Jun 7Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespanExperiments in miceAmino acid metabolismPaper
Diabetes & Metabolism Journal·Mar 30Hyperinsulinemia in Obesity, Inflammation, and CancerReviewMechanismsPaper
The Journal of Biological Chemistry·Jul 31Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restrictionExperiments in miceMechanismsPaper
The American Journal of Clinical Nutrition·Dec 1A ketone monoester drink reduces the glycemic response to an oral glucose challenge in individuals with obesity: a randomized trialRandomized trial in 15 peopleObesityPaper
Scientific Reports·Jul 29Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brainExperiments in miceMetforminPaper
Cell Metabolism·Nov 7System-wide Benefits of Intermeal Fasting by AutophagyExperiments in miceInterventionsPaper
Cell Reports·Jul 11Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends LifespanExperiments in miceMechanismsPaper
Frontiers in Neuroscience·Feb 24Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly SubjectsRandomized trial in peopleInsulinPaper