A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.