Cell surface ATP6V1B2

1. Cell surface ATP6V1B2 is associated with resistance to apoptosis in cells.

   “we show that csV1B2 expression correlates with senescent cell resistance to ABT-737-induced apoptosis in culture.”

   CellsABT-737-induced apoptosis in culturesenescent cells

   Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis

   bioRxiv (Cold Spring Harbor Laboratory)·1 Dec 2025Preprint

1. Cell surface ATP6V1B2 is associated with intracellular pH in cells.

   “This upregulation is associated with altered lysosomal activity and changes in intracellular pH.”

   Cellsfollowing DNA damagesenescent cells

   Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis

   bioRxiv (Cold Spring Harbor Laboratory)·1 Dec 2025Preprint

More on Intracellular pH

1. Cell surface ATP6V1B2 is associated with lysosomal activity in cells.

   “This upregulation is associated with altered lysosomal activity and changes in intracellular pH.”

   Cellsfollowing DNA damagesenescent cells

   Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis

   bioRxiv (Cold Spring Harbor Laboratory)·1 Dec 2025Preprint