CausAge

1. Alcohol use disorder has no effect on CausAge in humans.

   “none of the causality-enriched epigenetic clocks demonstrated significant associations with AUD.”

   Humansn = 615

   Alcohol and aging: Next-generation epigenetic clocks predict biological age acceleration in individuals with alcohol use disorder

   Alcohol, clinical & experimental research·Mar 28, 2025

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1. CausAge is associated with amyloid-beta 42 in humans (β [SE] = -4.9e-05 [1.6e-05], p =0.002).

   “Additionally, there was a synergistic interaction between CausAge and TL on CSF Aβ 42 (‐4.9e‐05 [1.6e‐05], p =0.002), Aβ 42 levels were lower in individuals with higher CausAge and shorter telomeres.”

   Humansinteraction with shorter telomere lengthcerebrospinal fluidn = 640

   Interactive effects of telomere length, mtDNA abundance, and epigenetic age on Alzheimer’s disease endophenotypes

   AAIC 2025 abstract·Dec 23, 2025

More on Amyloid-beta 42

1. CausAge predicts language ability in humans (β = -0.059 ± 0.028, p = 0.038).

   “older DNAm age predicted poorer language performance (β = -0.059 ± 0.028, p = 0.038).”

   Humansat higher mtDNAcnn = 640

   Integrative effects of Telomere Length, Epigenetic Age, and Mitochondrial DNA abundance in Alzheimer's Disease

   medRxiv : the preprint server for health sciences·Jul 17, 2025Preprint