DamAge
Biomarker1 paper
- Human trial1
Funding
National Institute on AgingUS$3mNational Institute of Neurological Disorders and StrokeUS$1.5mNational Heart, Lung, and Blood InstituteUS$1.3m23 grants since 2007
A non-invasive auscultation device for early detection of articular cartilage damage
National Institute on AgingKneevoice, Inc.US$398.4k2026–2027
Developing Human Proteins that Suppress DNA Damage
National Institute on AgingBaylor College of MedicineUS$440k2026–2028
National Cancer InstituteFramergy, Inc.US$400k2026–2027
Reprogramming inflammation via the DNA damage response-Metabolic axis control
European Research CouncilKarolinska Institutet€2.5m2026–2031
National Institute of Allergy and Infectious DiseasesUniversity of IowaUS$155.5k2025–2027
Comparative analysis of DNA damage and repair capacity in dogs to improve cancer risk prediction
NIH Office of the DirectorBroad Institute, Inc.US$125.7k2025–2030
Understanding and Targeting the R-Loop-Mediated DNA Damage Response at Telomeres
National Cancer InstituteDuke UniversityUS$368.3k2023–2028
Advancing a telomere extension biologic to treat alcohol-associated liver damage to IND
National Institute on Alcohol Abuse and AlcoholismRejuvenation Technologies, Inc.US$2.1m2026–2028
Aging, Burn Trauma, and Liver Damage
National Institute of General Medical SciencesUniversity of Colorado, DenverUS$335.4k2024–2029
National Heart, Lung, and Blood InstituteUniversity of Texas Hlth Sci Ctr HoustonUS$568.9k2016–2028
Latest
377New protein form pushed lab-grown cells to stop dividing
Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop…Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.
Older patients had hearing loss at lower chemotherapy doses
An observational study of 316 people with head and neck cancer tracked hearing during treatment with cisplatin, a chemotherapy drug.An observational study of 316 people with head and neck cancer tracked hearing during treatment with cisplatin, a chemotherapy drug.
A protein helped egg cells from aged cattle mature in the lab
In laboratory experiments, injecting instructions for making a protein reduced maturation failure in aged cattle egg cells and restored the function…In laboratory experiments, injecting instructions for making a protein reduced maturation failure in aged cattle egg cells and restored the function of their energy-producing structures.
Differences of oxidative damage in the brain of short- and long-lived Nothobranchius furzeri strains
Older age was linked to more DNA deletions in human colon
Simple DNA deletion counts showed an overall roughly 10-fold increase across ages 0.8 months to 90 years in people without radiation or chemotherapy…Simple DNA deletion counts showed an overall roughly 10-fold increase across ages 0.8 months to 90 years in people without radiation or chemotherapy treatment.
DNA damage differed by sex in mice with impaired DNA repair
Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic…Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic profiles in females.
Placentas showed faster molecular aging in late-onset preeclampsia
An analysis of placental tissue linked the pregnancy complication to shorter chromosome ends, DNA damage and cells that had stopped dividing.An analysis of placental tissue linked the pregnancy complication to shorter chromosome ends, DNA damage and cells that had stopped dividing.
Three-protein combination eased chronic liver disease in rats
In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased…In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.