Calcification
Biomarker1 paper2 findings
- Humans1
Interventions
1SGLT2 inhibitors
downin human cells1Low certainty
1 study
SGLT2 inhibitors
downin human cells1Low certainty
SGLT2 inhibitors decrease calcification in human cells.
CellsVICs cultured in SGLT2i-treated-endothelial mediumvalve interstitial cells
Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis · Cardiovascular research · 7 Sep 2026
Upstream
1SIRT1
downin human cells1
1 study
SIRT1
downin human cells1
SIRT1 decreases calcification in human cells.
CellsCRISPR/Cas9 knockdown or overexpressionvalve interstitial cells
Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis · Cardiovascular research · 7 Sep 2026
Funding
National Heart, Lung, and Blood InstituteUS$1.3mNational Institute on AgingUS$2.6mNational Institute of Dental and Craniofacial ResearchUS$150.4k4 grants since 2023
National Heart, Lung, and Blood InstituteMayo Clinic RochesterUS$712.4k2025–2029
National Institute of Dental and Craniofacial ResearchState University New York Stony BrookUS$150.4k2025–2027
Molecular mechanisms of calcification: roles and opportunities in diseases of aging
National Institute on AgingMedical College of WisconsinUS$2.6m2023–2028
The Role of Arylsulfatase in Vascular Calcification
National Heart, Lung, and Blood InstituteMassachusetts General HospitalUS$616k2023–2027
Latest
94Incidental detection of carotid artery calcification on CBCT: A retrospective analysis of 890 scans (108 cases)
Software measures age-related calcium deposits on brain scans
Automated deposit volumes closely tracked manual measurements, with a correlation of 0.964, in a study using scans from 106 people.Automated deposit volumes closely tracked manual measurements, with a correlation of 0.964, in a study using scans from 106 people.
Automated assessment of breast arterial calcification: a new frontier in cardiovascular risk prediction
TMEM174 deficiency shortens lifespan and stiffens vessels in mice
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality.
Calcium overload impairs muscle regeneration by driving sustained NFAT signaling
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.
Deep learning matches experts in scoring aortic valve calcium
Algorithm scores correlated strongly with expert assessments at r = 0.99, identifying moderate-to-severe aortic stenosis with 0.92 sensitivity and…Algorithm scores correlated strongly with expert assessments at r = 0.99, identifying moderate-to-severe aortic stenosis with 0.92 sensitivity and 0.98 specificity.
CT biomarkers improve postoperative mortality prediction
Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.