Myelin content

1. High-intensity interval training increases myelin content in humans (Cohen’s d=0.68, p=0.06).

   “medium to large effect on sagittal stratum myelin content (Cohen’s d=0.68, p=0.06)”

   Human trialsagittal stratum12-weeksfemalesn = 6

   FEASIBILITY AND EFFECTS OF HIGH-INTENSITY INTERVAL TRAINING ON COGNITIVE FUNCTION AND BRAIN HEALTH IN PERIMENOPAUSE

   GSA 2024 abstract·31 Dec 2024

More on High-intensity interval training

1. Myelin content mediates physical function in humans.

   “Myelin content revealed a significant indirect mediated effect on the relationship between high iron content and motor function in the superior corona radiata”

   Humansrelationship between high iron content and motor functionsuperior corona radiata

   Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin

   NeuroImage·15 Jan 2026

1. [18f]flutemetamol is associated with myelin content in humans.

   “The present study supports the binding of [18F]flutemetamol to myelin.”

   Humanswhite matter

   Regional distribution of an amyloid radiotracer in healthy aged human brain measured by PET with [¹⁸F]flutemetamol: a relation with myelin distribution

   Annals of nuclear medicine·23 Jan 2026

More on [18f]flutemetamol

1. HDL is associated with myelin content in humans (standardized B 0.344, 95% CI 0.096 to 0.592, p = 0.007).

   “HDL was positively associated with myelin content in the body of the corpus callosum (0.344 [0.096 to 0.592], p = 0.007, q = 0.037)”

   Humanscerebral small vessel disease and mild cognitive impairmentcorpus callosumn = 81

   Myelin content in older individuals with cerebral small vessel disease: the role of physical activity and lipids

   AAIC 2025 abstract·23 Dec 2025

More on HDL

1. Physical activity is associated with myelin content in humans (standardized B 0.331, 95% CI 0.114 to 0.549, p = 0.003).

   “Physical activity was positively associated with HDL (standardized B [95% CI] = 0.253 [0.037 to 0.470], p = 0.022) as well as with myelin content in the anterior corona radiata (0.225 [0.004 to 0.445], p = 0.046), genu of the corpus callosum (0.261 [0.040 to 0.482], p = 0.022), and sagittal stratum (0.331 [0.114 to 0.549], p = 0.003).”

   Humanscerebral small vessel disease and mild cognitive impairmentsagittal stratumn = 81

   Myelin content in older individuals with cerebral small vessel disease: the role of physical activity and lipids

   AAIC 2025 abstract·23 Dec 2025

More on Physical activity