CP

1. CP inhibits AMPK/p53 signaling in mouse cells.

   “Mechanistically, CP suppressed ES-Cu-induced AMPK/p53 pathway activation during osteoclastogenesis.”

   Cellselesclomol-copper treatment during osteoclastogenesisosteoclast

   Copper-binding protein deficiency linked to higher bone mass in mice

   Scientific reports·8 Oct 2026

1. CP decreases cuproptosis-related gene expression in mouse cells.

   “CP downregulated the expression of cuproptosis-related genes ( Lipt1 , Gls , Pdhb , Fdx1 , Dlat , and Pdha1 ) in osteoclasts.”

   Cellsosteoclast

   Copper-binding protein deficiency linked to higher bone mass in mice

   Scientific reports·8 Oct 2026

More on Cuproptosis-related gene expression

1. CP increases bone resorption in mouse cells.

   “Our research found that CP inhibited elesclomol-copper (ES-Cu)-induced osteoclast cuproptosis-like cell death, thereby promoting osteoclast formation and overall bone resorption.”

   Cellselesclomol-copper treatmentosteoclast

   Copper-binding protein deficiency linked to higher bone mass in mice

   Scientific reports·8 Oct 2026

1. CP inhibits osteoclast cuproptosis-like cell death in mouse cells.

   “Our research found that CP inhibited elesclomol-copper (ES-Cu)-induced osteoclast cuproptosis-like cell death, thereby promoting osteoclast formation and overall bone resorption.”

   Cellselesclomol-copper-induced cell deathosteoclast

   Copper-binding protein deficiency linked to higher bone mass in mice

   Scientific reports·8 Oct 2026