2 papers4 findings
Gastric bypass
downin humans1
Gastric bypass decreases bone marrow adipose tissue in humans.
“Overall, gastric bypass appears to decrease BMAT, particularly in patients with diabetes and postmenopausal women, whereas sleeve gastrectomy appears to increase BMAT”
Reviewparticularly in patients with diabetes and postmenopausal women
NutrientsOct 29, 2023
Caloric restriction
downin humans1
Caloric restriction decreases bone marrow adipose tissue in humans.
“BMAT levels tend to decrease after caloric restriction-induced weight loss”
Reviewin people living with obesity
NutrientsOct 29, 2023
High-fat diet
upin mice1
High-fat diet increases bone marrow adipose tissue in mice (+79.5 ± 5.86%, p < 0.005).
“expansion of bone marrow adipose tissue (BMAT; +60.7 ± 9.9% in HFD vs. +79.5 ± 5.86% in HFD-OVX, p < 0.005).”
Animalsin ovariectomized mice60% fatbone12 weeksfemales
Aging cellOct 10, 2022
Bone mineral density
downin humans1
Bone marrow adipose tissue is associated with bone mineral density in humans.
“inverse associations between BMAT and bone mineral density (BMD) have been consistently found in PwO”
Reviewin people living with obesity
NutrientsOct 29, 2023
National Institute of Diabetes and Digestive and Kidney DiseasesUS$34.3kDanmarks Frie Forskningsfond
In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.