B-1a cell numbers

1. BCL11A increases B-1a cell numbers in mice.

   “Bcl11a deletion reduced B-1a cell numbers, impaired viability, and increased apoptosis across sexes and ages.”

   Animalsshown by Bcl11a deletionB-1a cell

   The transcription factor Bcl11a is essential for B-1a cell maintenance during aging

   Proceedings of the National Academy of Sciences of the United States of America·3 Jul 2025

More on BCL11A

1. Female sex is associated with B-1a cell numbers in mice.

   “aged females retain higher B-1a cell numbers than males, correlating with enhanced glycolysis and chromatin accessibility.”

   Animalsfemales compared with malesB-1a cell

   The transcription factor Bcl11a is essential for B-1a cell maintenance during aging

   Proceedings of the National Academy of Sciences of the United States of America·3 Jul 2025