ATG5-12 complex

1. Sleep deprivation decreases ATG5-12 complex in mice.

   “Males, however, demonstrated autophagic impairments through reductions in the autophagy‐initiating ATG5‐12 complex”

   Animalschronic sleep loss in male DKI micehippocampusmales

   Sleep Deprivation is associated with autophagic impairment and Alzheimer's‐related pathology in the orexinergic ‐ locus coeruleus ‐ hippocampal circuit

   AAIC 2025 abstract·24 Dec 2025

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