ASXL1 clonal hematopoiesis
Biomarker2 papers2 findings
- Humans2
Effects
1Aortic valve hemodynamics
downin humans1
1 study
Aortic valve hemodynamics
downin humans1
ASXL1 clonal hematopoiesis impairs aortic valve hemodynamics in humans.
Humansin ARIC study participants
ASXL1-mutant clonal hematopoiesis links to aortic valve disease · medRxiv · 29 Sep 2026 · Preprint
Associations
1Smoking
upin humans1Low certainty
1 study
Smoking
upin humans1Low certainty
Smoking is associated with ASXL1 clonal hematopoiesis in humans.
Humansin lung cancer
ASXL1 clonal hematopoiesis is linked to lung cancer risk · Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 28 Sep 2026
Latest
2ASXL1-mutant clonal hematopoiesis links to aortic valve disease
In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or…In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.
ASXL1 clonal hematopoiesis is linked to lung cancer risk
In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among…In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers.