anti-dsDNA antibodies

1. Fish oil decreases anti-dsDNA antibodies in mice.

   “4% Lovaza® significantly decreased anti-dsDNA antibodies”

   Animalscompared to placebo4%

   Concentrated fish oil (Lovaza(R)) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW)F1 mice

   Experimental biology and medicine (Maywood, N.J.)·1 Jun 2013

2. Fish oil decreases anti-dsDNA antibodies in mice.

   “decreased serum anti-dsDNA Ab titers in the FO group compared with the CO group”

   Animalsin (NZB/NZW) F1 (B/W) micefish oil semipurified diet10%females

   Increased TGF-beta and decreased oncogene expression by omega-3 fatty acids in the spleen delays onset of autoimmune disease in B/W mice

   Journal of immunology (Baltimore, Md. : 1950)·15 Jun 1994

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1. INDOLE-3-CARBINOL decreases anti-dsDNA antibodies in mice.

   “Anti-double-stranded DNA (dsDNA) antibodies developed in all groups, although at several time points, the levels produced in I3C-fed mice were significantly lower.”

   Animalsin female (NZB x NZW) F1 mice0.2 g/kgfemales

   Lifespan is prolonged in autoimmune-prone (NZB/NZW) F1 mice fed a diet supplemented with indole-3-carbinol

   The Journal of nutrition·1 Nov 2003

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1. Caloric restriction decreases anti-dsDNA antibodies in mice.

   “CR mice had fewer palpable lymph nodes, and decreased serum anti-dsDNA antibodies.”

   AnimalsMRL/lpr micefemales

   Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice

   Immunology letters·1 Sep 1995

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