Amyloid PET positivity

1. Educational attainment decreases amyloid PET positivity in humans (β=‐0.12[0.05], p = 0.02).

   “In CU, higher education was associated with lower amyloid‐positivity frequency (β=‐0.12[0.05], p = 0.02).”

   Humanscognitively unimpaired individuals

   Sex, education and race/ethnicity have distinct effects on amyloid and tau‐PET status

   AAIC 2025 abstract·8 Jan 2026

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1. Female sex increases amyloid PET positivity in humans (β=0.51[0.22], p = 0.02).

   “Female sex was associated with an APOEε4 ‐independent increased frequency of amyloid‐positivity (β=0.51[0.22], p = 0.02) in CU”

   Humanscognitively unimpaired individuals

   Sex, education and race/ethnicity have distinct effects on amyloid and tau‐PET status

   AAIC 2025 abstract·8 Jan 2026

1. GFAP has no effect on amyloid PET positivity in humans.

   “GFAP and NfL did not contribute significantly to amyloid detection in either group.”

   Humansin both CU and CI individuals

   Plasma phosphorylated tau 217 and amyloid‐β 42/40 for amyloid risk in subgroups

   AAIC 2025 abstract·23 Dec 2025

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1. Hearing loss has no effect on amyloid PET positivity in humans (OR=0.96 [0.72, 1.28], p = 0.780).

   “Baseline PTA was not a significant predictor of incident amyloid PET positivity seven years later (OR=0.96 [0.72, 1.28], p = 0.780).”

   Humansseven years51.3% femalesn = 461

   Hearing Loss and Amyloid Pathology: A Bidirectional Study

   AAIC 2025 abstract·23 Dec 2025

1. APOE is associated with amyloid PET positivity in humans.

   “n = 61 participants adjudicated as PET‐positive were significantly older and had greater APOEε4 carriage”

   HumansPET-positive vs PET-negativen = 113

   Approaches to a center‐specific CSF amyloid ratio cutoff based on PET‐amyloid positivity at the Wake Forest Alzheimer's Disease Research Center

   AAIC 2025 abstract·9 Jan 2026

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1. Aβ42/Aβ40 ratio predicts amyloid PET positivity in humans (OPA 92.0%, PPA 94.2%, NPA 90.2%).

   “The center‐specific cutoff was ≤0.064, resulting in PPA of 94.2%, NPA of 90.2%, and OPA of 92.0%.”

   Humanscenter-specific cutoff ≤0.064cerebrospinal fluidn = 113

   Approaches to a center‐specific CSF amyloid ratio cutoff based on PET‐amyloid positivity at the Wake Forest Alzheimer's Disease Research Center

   AAIC 2025 abstract·9 Jan 2026

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1. Plasma pTau217 predicts amyloid PET positivity in humans (MAE = 3.5 years; ρ = 0.629).

   “Beyond 30 CL, plasma and PET estimates of time‐to‐positivity correlated well (MAE = 3.5 years; ρ = 0.629)”

   Humanscortical amyloid burden > 30 CL

   Plasma pTau217 as a marker of both the current and future state of amyloid pathology in adults with DS

   AAIC 2025 abstract·25 Dec 2025

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1. Semantic intrusion errors are associated with amyloid PET positivity in humans.

   “SIEs have been found to be highly discriminative between those with amnestic Mild Cognitive Impairment (aMCI) with amyloid PET positivity.”

   Humansin amnestic mild cognitive impairment

   Innovative Modifications to the LASSI‐L Cognitive Challenge Test

   AAIC 2025 abstract·24 Dec 2025

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1. Amyloid PET positivity raises the risk of mild cognitive impairment or dementia in humans (from 9.09% to 42.42%).

   “percentage of progressors in the A+T‐ group increased from 9.09% to 42.42%”

   Humans

   The clinical prognosis of cognitively unimpaired individuals with positive PET biomarkers

   AAIC 2025 abstract·24 Dec 2025

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1. Amyloid PET positivity is associated with ECOG visuospatial scores in humans (t = 3.4, p = 0.001).

   “ECOG visuospatial scores were higher in PiB+ individuals compared to PiB‐ individuals ( t = 3.4, p = 0.001).”

   Humanscognitively unimpairedn = 253

   Subjective Visuospatial Decline in Cognitively Unimpaired Individuals

   AAIC 2025 abstract·23 Dec 2025

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1. Diabetes is associated with amyloid PET positivity in humans.

   “We found that diabetes and, to a lesser extent, hypertension were associated with a higher risk of amyloid PET positivity at follow‐up”

   Humansbrainseven years

   Modifiable dementia risk factors differentially relate to intermediate brain and cognitive outcomes in the population‐based Rotterdam Study

   AAIC 2025 abstract·23 Dec 2025

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