Aβ42/40

1. IgM increases Aβ42/40 in humans.

   Humansplasma

   Genetic evidence suggests a protective role of immunoglobulin M in Alzheimer's disease · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Sep 2026

IgM →

1. Aβ42/40 is associated with ganglion cell-inner plexiform layer thickness in humans.

   HumansCognitively normal adults; APOE ε4-dependent interaction; not significant after FDR correctionretinan = 44

   Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults · Translational vision science & technology · 5 Oct 2026

Ganglion cell-inner plexiform layer thickness →