Amyloid-beta deposit

Biomarker

2 papers2 findings

  • Animals2

Interventions

1

Taurine

downin mice1

1 study
  1. Taurine decreases amyloid-beta deposit in mice.

    “taurine significantly reduced the number of activated microglia, levels of phospho-tau and Aβ deposit in the hippocampus and cortex.”

    Animalsaged SAMP8 micewaterbrain1%

    Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2

    Scientific reports28 Mar 2024

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Upstream

1

CAT

downin mice1

1 study
  1. CAT decreases amyloid-beta deposit in mice.

    “reduction in the levels of full-length APP, CTF99, BACE1, Aβ levels (40 and 42), Aβ deposits and oxidative DNA damage relative to the brain sections from the AβPP mice.”

    Animalsin AβPP transgenic micebrain

    Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

    Human molecular genetics5 Apr 2012

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