What does the research say about AMP/ATP ratio?

AMP/ATP ratio

There are 9 papers on AMP/ATP ratio in aging research: none in people yet, 4 in animals, 2 in cells, 3 reviews. The newest story, Nov 9, 2026: “Blocking a fuel carrier may reduce kidney scarring in mice”.

Biomarker

9 papers study it1 more mentions it2 findings

1 new paper in 30 daysSee all 10 papers on AMP/ATP ratio

Animals3
Model organisms1
Cells2

Upstream

Cellular senescence

upin cells1

1 study

Cellular senescence increases AMP/ATP ratio in cells.
“The AMP:ATP ratio increased in senescent PDLSCs”
Cells
Metabolomics Dysfunction in Replicative Senescence of Periodontal Ligament Stem Cells Regulated by AMPK Signaling Pathway
Stem cells and developmentSep 21, 2024

Associations

NAD+

downin mice1

1 study

AMP/ATP ratio is associated with NAD+ in mice (ischemic stroke models).
“an increased AMP/ATP ratio correlates with NAD+ decline in ischemic stroke models”
Animalsischemic stroke models
The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress
Molecular cellJun 1, 2025

Latest

3 papers in 12 months

AHA Scientific Sessions 2026 AbstractNov 9

Blocking a fuel carrier may reduce kidney scarring in mice

In experiments with 22-month-old mice, a drug reduced kidney scarring and restored activity of genes involved in using fat for energy.In experiments with 22-month-old mice, a drug reduced kidney scarring and restored activity of genes involved in using fat for energy.

Mouse studyKidney