Age-related transcriptional changes

Biomarker

2 papers2 findings

  • Humans2

Upstream

1

Dorsal striatum

upin humans1

1 study
  1. Dorsal striatum increases age-related transcriptional changes in humans.

    “we find that the dorsal zones exhibit greater age-related transcriptional changes”

    Humansstriatum

    Mesoscale molecular architecture of the human striatum across cell types and lifespan

    bioRxiv : the preprint server for biology5 Mar 2026Preprint

Associations

1

Neuronal resilience

downin humans1

1 study
  1. Neuronal resilience is associated with age-related transcriptional changes in humans.

    “Resilient neurons showed a weaker association with age-related transcriptional changes”

    Humansresilient versus vulnerable neuronsbrain neurons

    A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson’s disease susceptibility

    bioRxiv (Cold Spring Harbor Laboratory)2 Dec 2025Preprint

Latest

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Science Advances

SATB1 loss reshapes 3D genome in mouse naive T cells

Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.

Experiments in miceBlood and immune system