1 paper4 findings
Smoking
upin humans1
Smoking increases Age difference in humans.
“smoking females are biologically older”
Humansfemales
Aging cell1 Mar 2026
Hormone replacement therapy
downin humans1
Hormone replacement therapy decreases Age difference in humans.
“postmenopausal females taking hormone replacement therapy are biologically younger”
Humansfemales
Aging cell1 Mar 2026
Down syndrome
upin humans1
Down syndrome increases Age difference in humans.
“subjects with Down Syndrome and smoking females are biologically older”
HumansDown Syndrome
Aging cell1 Mar 2026
HDL
downin humans1
HDL is associated with Age difference in humans.
“age difference of MARK-AGE subjects, but not chronological age, is linearly correlated with levels of HDL, 25-hydroxy-Vitamin D, and CD3+ CD4+/CD45+ ratio”
Humans
Aging cell1 Mar 2026
Brain scans from 4,098 women revealed greater gray matter volume and cortical thickness in specific regions among post-menopausal compared with pre-menopausal women.Brain scans from 4,098 women revealed greater gray matter volume and cortical thickness in specific regions among post-menopausal compared with pre-menopausal women.
Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.
The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.