AD polygenic risk score

1. AD polygenic risk score has no effect on AD plasma biomarkers in humans.

   “We showed that the PRSAD did not associate with biomarker concentrations over age.”

   Humanspolygenic risk score excluding APOE; association over ageplasma64.1% femalessn = 5,913

   Alzheimer’s risk variant linked to steeper blood-marker changes

   Nature communications·Oct 17, 2026

More on AD plasma biomarkers

1. AD polygenic risk score has no effect on neurodegeneration pathology in humans (β=0.039, p =0.21).

   “AD‐PRS was significantly associated with the AD (β=0.089, p =8.22e‐3) but not with the neurodegeneration latent variable (β=0.039, p =0.21).”

   Humansn = 1,890

   Orthogonal Contributions of Genetic and Clinical Risk Factors on Alzheimer’s Disease and Neurodegenerative Pathogenesis

   AAIC 2025 abstract·Dec 23, 2025

1. AD polygenic risk score predicts Alzheimer's disease in humans.

   “multi‐ancestry AD‐PRS and PRS‐CSx were predictive of AD risk.”

   Humansin 1KG-AFR-like and 1KG-AMR-like participants

   Genomic‐informed dementia risk reports for equitable personalized medicine to promote brain health

   AAIC 2025 abstract·Dec 24, 2025

More on Alzheimer's disease

1. AD polygenic risk score is associated with alzheimer's disease pathology in humans (β=0.089, p =8.22e‐3).

   “AD‐PRS was significantly associated with the AD (β=0.089, p =8.22e‐3) but not with the neurodegeneration latent variable (β=0.039, p =0.21).”

   Humansn = 1,890

   Orthogonal Contributions of Genetic and Clinical Risk Factors on Alzheimer’s Disease and Neurodegenerative Pathogenesis

   AAIC 2025 abstract·Dec 23, 2025

1. AD polygenic risk score raises the risk of dementia in humans (HR = 1.79, 95% CI: 1.70-1.87, P < 0.001).

   “AD PRS was associated with a 79% higher risk for all-cause dementia for each unit increase (HR = 1.79, 95% CI: 1.70-1.87, P < 0.001).”

   Humans≤ 15 yn = 40,139

   Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults

   GeroScience·Nov 26, 2024

More on Dementia