1 paper3 findings
Cognitive benefits of multidomain lifestyle intervention
no changein humans1
AD plasma biomarkers have no effect on cognitive benefits of multidomain lifestyle intervention in humans.
“We found no indication that baseline biomarker levels significantly modified the cognitive benefits of the intervention.”
Human trialeffect modification by baseline biomarker levelstwo years
Lifestyle trial found similar Alzheimer’s blood marker changes
medRxiv6 Oct 2026Preprint
BDNF
no changein humans1
BDNF has no effect on AD plasma biomarkers in humans.
“No associations emerged among pain-free individuals.”
HumansPain-free individuals; BD-tau and ptau217plasma
Journal of Alzheimer's disease reports16 Jul 2026
Cognitive trajectories
downin humans1
AD plasma biomarkers are associated with cognitive trajectories in humans.
“Higher biomarker levels were associated with less favorable cognitive trajectories over two years”
Human trialat risk of dementiatwo years
Lifestyle trial found similar Alzheimer’s blood marker changes
medRxiv6 Oct 2026Preprint
Alzheimer's Association
An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.
A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.