BD-tau

1. Sodium lactate decreases BD-tau in humans (p < 0.001).

   “reductions in plasma BD‐tau ( p <0.001), pTau217 ( p <0.001), pTau181 ( p <0.001), GFAP ( p <0.001), and NfL ( p <0.001) in both AD and CH groups after lactate infusion”

   Human trialplasma120 minutes

   Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition; the LEAN study

   AAIC 2025 abstract·8 Jan 2026

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1. BD-tau has no effect on cognitive decline in humans.

   “Elevated BD‐tau in individuals with low p ‐tau217 was not associated with greater hazards.”

   Humansin individuals with low p-tau217plasma

   Combining p ‐tau217 with Other Blood Biomarkers to Enhance Prediction of Cognitive Decline: A Large Memory Clinic Cohort Study

   AAIC 2025 abstract·8 Jan 2026

1. Blood donors are associated with BD-tau in humans (35% (95% CI, 29%-41%)).

   “Plasma BD-tau concentrations exceeded the study-specific threshold in 89 of 257 samples (35%; 95% CI, 29%-41%).”

   Humansplasman = 257

   Elevation in Plasma p-tau217 Concentrations Among Blood Donors: An Exploratory Cross-Sectional Study

   medRxiv : the preprint server for health sciences·24 Sep 2026Preprint

1. BD-tau is associated with total tau in humans (R=0.99).

   “BD‐Tau measurements showed very high correlation with t‐Tau in CSF samples (R=0.99)”

   HumansCSF samplesCSFn = 86

   Highly Sensitive Multiplexed Detection of Brain‐Derived Tau and Phosphorylated Tau Proteoforms with the NULISA Technology

   AAIC 2025 abstract·25 Dec 2025

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