Aβ oligomers

2 papers2 findings

Animals1
Model organisms1

Interventions

2

[azagly6]-1

downin mice1

1 study

[azagly6]-1 decreases Aβ oligomers in mice.
“reduced Aβ oligomer levels”
AnimalsAD models
Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers
Proceedings of the National Academy of Sciences of the United States of America28 Nov 2022

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Fluoxetine

downin worms1

1 study

Fluoxetine decreases Aβ oligomers in worms.
“delayed Abeta-induced paralysis in the C. elegans model of Abeta toxicity by reducing Abeta oligomers.”
Model organismsin C. elegans model of Abeta toxicity
Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
Neuropharmacology24 Apr 2010

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Latest

6 in 12 months

Journal of Alzheimer's Disease ReportsYesterday

The single cell origin of sporadic Alzheimer's disease: A developmental biallelic somatic mutation model

ReviewMechanisms

Nutrients13 Aug

Phycocyanobilin Attenuates Oligomerized Amyloid β-Induced Neuronal Senescence Through SIRT1-Associated Mechanisms

Experiments in human cellsInterventions

Mathematical Medicine and Biology17 Jul

Predicting biological age using an accumulated neurotoxicity biomarker for amyloid beta oligomers

Computational studyBiomarkers

AAIC 2025 Abstract24 Dec

Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation

Experiments in miceInflammation

AAIC 2025 Abstract23 Dec

Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation

Experiments in miceInflammation

AAIC 2025 Abstract23 Dec

Proteasome Activation as a Therapeutic Strategy to Rescue Cognitive Decline in Aging and Alzheimer’s Disease

Experiments in miceAlzheimer's disease

Mechanisms of Ageing and Development27 Sep

Human astrocytes from healthy individuals and Alzheimer's patients respond differently to Aβ₁₋₄₂ oligomers, triggering distinct paths of reactivity and senescence

Experiments in cellsMechanisms

Research Square18 Jul

Global C3 lowering in adulthood protects against hippocampal dysfunction and cognitive impairment in aged mice

Preprint: experiments in animalsMechanisms

IBRO Neuroscience Reports24 Apr

Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation

Experiments in animalsInterventions

International Journal of Biological Macromolecules22 Dec

Tetrahydrofolic acid accelerates amyloid fibrillization, decreases cytotoxic oligomers and suppresses their toxicity

Experiments in wormsInterventions