Abeta

1. Rapamycin increases Abeta in mouse cells.

   “rapamycin (2.5muM), significantly increases Abeta generation in murine neuron-like cells (N2a) transfected with the human "Swedish" mutant amyloid precursor protein (APP).”

   Cellsmurine neuron-like cells (N2a) transfected with human Swedish mutant APP2.5muM

   Rapamycin promotes beta-amyloid production via ADAM-10 inhibition

   Biochemical and biophysical research communications·11 Jun 2010

More on Rapamycin

1. FOXO3 increases Abeta in mouse cells.

   “causally promotes AD amyloid-beta peptide (Abeta) levels by inhibiting nonamyloidogenic alpha-secretase activity”

   Cellsconstitutively active FoxO3a in primary neuron cultures from Tg2576 mouse embryos

   Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration

   Annals of the New York Academy of Sciences·1 Dec 2008

More on FOXO3

1. Abeta raises the risk of Alzheimer's disease dementia in humans.

   “After full adjustment, Aβ+ status was associated with greater hazards for dementia HR:1.73(95%CI:1.10–2.70); p =.016.”

   Humansafter full adjustment

   Synergistic effects of GFAP with TNFR1 and TNFR2 on conversion to AD dementia and overall survival across the Alzheimer’s disease spectrum

   AAIC 2025 abstract·23 Dec 2025

More on Alzheimer's disease dementia