MechanismsAnimals

A Gene X Environment Study of a Novel Preclinical Mouse Model: The Humanized Mthfr*677C>T Allele and Inorganic Arsenic in Late‐Onset Alzheimer's Disease Progression

AAIC 2025 Abstract

Abstract

Background: Current mouse models fail to adequately capture the clinical variability and genetic complexity of late‐onset Alzheimer's disease (LOAD), limiting their utility for preclinical therapeutic development.

The paper

Sarica Z, Kotredes KP, Reagan AM et al.

AAIC 2025 Abstract · 24 Dec 2025 · CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70855_106540