There are 3 papers on aberrant DNA methylation in aging research: 1 observational study in people, 1 in cells, 1 review.
3 papers study it26 more mention it2 findings
1 new paper in 30 daysSee all 29 papers on aberrant DNA methylation
“Aberrant DNA methylation was observed in the gene PRDM8 in DKC and AA as well as in other diseases with premature aging phenotype”
- Humans1
- Cells1
Interventions
1Spermine
downin reviews1
1 study
Spermine
downin reviews1
Spermine decreases aberrant DNA methylation in vitro, after ornithine decarboxylase inhibition.
“In vitro studies demonstrated that spermine reversed changes induced by the inhibition of ornithine decarboxylase (e.g., increased decarboxylated S-adenosylmethionine, decreased DNA methyltransferase activity, increased aberrant DNA methylation)”
Reviewin vitro, after ornithine decarboxylase inhibition
Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet
Amino acids
Associations
1PRDM8
mixedin humans1
1 study
PRDM8
mixedin humans1
PRDM8 is associated with aberrant DNA methylation in dyskeratosis congenita, aplastic anemia and other premature aging syndromes.
“Aberrant DNA methylation was observed in the gene PRDM8 in DKC and AA as well as in other diseases with premature aging phenotype”
Humansin dyskeratosis congenita, aplastic anemia and other premature aging syndromesblood
Clinical epigenetics