Brazilian Journal of Development · May 25, 2026
Epigenetic mechanisms in skin aging: biological implications and therapeutic perspectives
By Moraes R
Skin aging is a complex and multifactorial biological process influenced by intrinsic and extrinsic factors, leading to progressive structural, functional, and cellular alterations. Epigenetic mechanisms, including DNA methylation, histone modifications, and microRNA regulation, play a central role in modulating gene expression without altering the DNA sequence. This study aimed to comprehensively analyze epigenetic mechanisms involved in skin aging and their biological and therapeutic implications. An integrative literature review was conducted using PubMed, Scopus, Web of Science, and Google Scholar, including studies published between 2015 and 2024. The results demonstrate that aberrant DNA methylation, histone deacetylation, and dysregulated microRNA expression contribute significantly to extracellular matrix degradation, oxidative stress, and cellular senescence. Furthermore, epigenetic-based interventions, including HDAC inhibitors, SIRT1 activators, and natural compounds such as resveratrol, have shown promising potential in reversing molecular damage associated with skin aging. Epigenetic modulation represents a promising and innovative strategy in dermatology, enabling personalized and mechanism-based therapeutic approaches.