There is 1 paper on PRDM8 in aging research: 1 observational study in people.
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country.
“Aberrant DNA methylation was observed in the gene PRDM8 in DKC and AA as well as in other diseases with premature aging phenotype”
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Bundesministerium für Forschung, Technologie und Raumfahrt and 3 more
- Humans1
Effects
2Epigenetic age
no changein human cells1
1 study
Epigenetic age
no changein human cells1
PRDM8 showed no clear effect on epigenetic age in human cells (PRDM8 knockout iPSCs).
“it did not impact on epigenetic age”
CellsPRDM8 knockout iPSCs
Clinical epigenetics
hematopoietic and neuronal differentiation
is required forin human cells1
1 study
hematopoietic and neuronal differentiation
is required forin human cells1
PRDM8 is required for hematopoietic and neuronal differentiation in human cells (heterozygous and homozygous PRDM8 knockout iPSCs).
“Loss of PRDM8 impaired hematopoietic and neuronal differentiation of iPSCs, even in the heterozygous knockout clone”
Cellsheterozygous and homozygous PRDM8 knockout iPSCs
Clinical epigenetics
Associations
1Aberrant DNA methylation
mixedin humans1
1 study
Aberrant DNA methylation
mixedin humans1
PRDM8 is associated with aberrant DNA methylation in dyskeratosis congenita, aplastic anemia and other premature aging syndromes.
“Aberrant DNA methylation was observed in the gene PRDM8 in DKC and AA as well as in other diseases with premature aging phenotype”
Humansin dyskeratosis congenita, aplastic anemia and other premature aging syndromesblood
Clinical epigenetics