92 results
In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.
A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.
Experiments in mice whose ovaries had been removed linked ceruloplasmin deficiency to higher bone mass at the tissue level.Experiments in mice whose ovaries had been removed linked ceruloplasmin deficiency to higher bone mass at the tissue level.
In 12-month-old Col4a2 mutant mice, cerebral pial arteries showed impaired myogenic tone driven by PKA-dependent remodeling of ryanodine receptor clusters.In 12-month-old Col4a2 mutant mice, cerebral pial arteries showed impaired myogenic tone driven by PKA-dependent remodeling of ryanodine receptor clusters.
An analysis of NHANES data identifies source-dependent effects and an optimal serum iron window between 15.2 and 18.8 micromoles per liter.An analysis of NHANES data identifies source-dependent effects and an optimal serum iron window between 15.2 and 18.8 micromoles per liter.
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.
Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice.Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice.
Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference.Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference.
Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.