Journal of Microbiology and Biotechnology

Kimchi bacterium increased muscle mass and strength in older mice

Grip strength was 28% higher than in controls after four months of daily dosing with a bacterial strain isolated from kimchi.

Paper by Sulhee Lee, Ga Hee Choi, Sang-Pil Choi, 9 more authorsHak-Jong Choi · World Institute of Kimchi
Experiments in aged male C57BL/6J mice, 4 months, against control preparationInterventions

Limit: The microbiota analysis measured associations, not whether bacterial community changes caused muscle benefits

Edited by Boris Djordjevic · AgingResearch.News

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Male C57BL/6J mice aged 18 months received the bacterium Weissella cibaria Wikim0187, isolated from kimchi, or a control preparation in a four-month experiment. Each supplemented mouse received a daily oral dose of 1 billion colony-forming units, a measure of live bacteria.

Compared with controls, supplemented mice had 12.4% greater mass in the gastrocnemius, a calf muscle, and 30.4% greater quadriceps muscle mass at the front of the thigh. Grip strength declined in both groups, but more slowly in supplemented mice. Muscle fibers were also larger on average. The researchers found lower activity of genes linked to muscle breakdown and higher activity of genes involved in muscle development. Gut bacterial communities changed, and several bacterial groups that became more common were associated with better muscle measurements.

Why it matters

Age-related loss of muscle mass and strength, called sarcopenia, has limited targeted treatment options. The authors proposed this bacterial strain as a potential intervention.

Caveats

This animal experiment did not establish effectiveness or safety in older people. The associations between gut bacteria and muscle measurements did not establish that changes in the bacteria caused the muscle benefits.