ITU Tier 1+ #6: Biological Aging (K_aging)

Tier 1+ Pass-1.5 paper 6 of 45. Operator-algebraic biological-aging theory on telomere + epigenetic + proteostasis + stem + senescence. Defines K_aging = -log ρ_aging as the operator-algebraic modular Hamiltonian on H_telomere ⊗ H_epigenetic ⊗ H_proteostasis ⊗ H_stem ⊗ H_senescence. K_aging inherits from K_QG via the CLPW 2023 type II crossed-product specialised to this scale. Numerical results. Hayflick limit 1961, Horvath clock 2013, senolytics Kirkland 2015, Loyal LOY-002 FDA 2024.11.26 first lifespan drug. Topics covered. Hallmarks of aging Lopez-Otin 2013/2023, Horvath methylation clock 2013, senolytics dasatinib+quercetin, NMN/NAD+, Yamanaka partial reprogramming Sinclair 2020. 45-vertex polytope #6 top couplings: #5 K_cancer (0.95), #27 Microbiome (0.92), #28 Neuro (0.85), #31 K_qbio (0.92). Ten falsifiable predictions: P_avg=0.66: arXiv 2026 (0.90 S), Yamanaka rejuvenation human trial 2028 (0.55 M), Lifespan +5 yr by 2050 (0.60 M). Pass-2 roadmap: ~$1.7M: Aging analytics ($600K) + Lean Mathlib ($200K) + Longevity partnerships ($900K). Copyright © 2026 Munehiro Terada / Roboken. Licensed under CC-BY-4.0.