SIRT1 Activation Combined with NAD+ Precursor Supplementation

SIRT1 deacetylase activity is impaired in progeria due to progerin-induced chromatin dysfunction and reduced NAD+ availability. Combined treatment with SIRT1 activators and NAD+ precursors like nicotinamide riboside enhances DNA repair, reduces p53 acetylation, and improves mitochondrial function in progeric cells.