Zenodo
Senolytic Therapy Targeting p16INK4a+ Senescent Chondrocytes
PreprintInterventions
Abstract
Combination of dasatinib and quercetin selectively eliminates p16INK4a-positive senescent chondrocytes in growth plates while promoting proliferation of healthy progenitor cells and restoring growth plate architecture through reduced SASP factor secretion
- Dasatinib + quercetin
- Cell cycle regulation
- Cellular senescence
- Senescence-associated secretory phenotype (SASP)
- CDKN2A
- p16INK4a-positive senescent chondrocytes
The paper
MedicOath
Zenodo, 28 Apr 2026, Open access, CC0, Preprint, not peer-reviewed
